Drug Information

Drug General Information
Drug ID
D0H9QN
Former ID
DIB003713
Drug Name
AZ-TAK1
Synonyms
TAK1 inhibitor (mantle cell lymphoma), AstraZeneca; TGF-beta-activated kinase 1 inhibitor (mantle cell lymphoma), AstraZeneca
Indication Mantle cell lymphoma [ICD9: 200.4, 202.8, 203.0, 208.9; ICD10:C81-C86, C85.7, C90.0, C91-C95] Investigative [543552]
Company
AstraZeneca plc
Target and Pathway
Target(s) Mitogen-activated protein kinase kinase kinase 7 Target Info Inhibitor [543552]
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
PANTHER Pathway TGF-beta signaling pathway
Toll receptor signaling pathway
Wnt signaling pathway
p38 MAPK pathway
Pathway Interaction Database BCR signaling pathway
p38 MAPK signaling pathway
Noncanonical Wnt signaling pathway
Presenilin action in Notch and Wnt signaling
IL1-mediated signaling events
TNF receptor signaling pathway
BMP receptor signaling
JNK signaling in the CD4+ TCR pathway
C-MYB transcription factor network
Ephrin B reverse signaling
TGF-beta receptor signaling
Reactome Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
TRAF6 mediated induction of TAK1 complex
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
Insulin Signaling
p38 MAPK Signaling Pathway
Wnt Signaling Pathway and Pluripotency
MAPK Signaling Pathway
TGF beta Signaling Pathway
IL-6 signaling pathway
FAS pathway and Stress induction of HSP regulation
NLR Proteins
MyD88 cascade initiated on plasma membrane
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
MyD88 dependent cascade initiated on endosome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
MyD88:Mal cascade initiated on plasma membrane
Fc epsilon receptor (FCERI) signaling
MyD88-independent cascade
Signaling by the B Cell Receptor (BCR)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Structural Pathway of Interleukin 1 (IL-1)
EBV LMP1 signaling
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
IL17 signaling pathway
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
TCR signaling
Interleukin-1 signaling
Regulation of toll-like receptor signaling pathway
References
Ref 543552(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2082).
Ref 543552(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2082).

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