Drug Information

Drug General Information
Drug ID
D0HE9J
Former ID
DIB002919
Drug Name
APN-201
Synonyms
Lipoxysan; Liposomal SOD (wound healing), Polymun; Liposomal SOD (Peyronie's disease), Polymun; RhSOD (liposomal, dermatitis), Apeiron; Liposomal superoxide dismutase (recombinant, encapsulated, topical), Polymun
Indication Dermatitis [ICD9: 692.9; ICD10:L20-L30] Phase 1/2 [523766]
Company
Polymun Scientific Immunobiologische Forschung GmbH
Target and Pathway
Target(s) Superoxide dismutase [Cu-Zn] Target Info Modulator [525361]
BioCyc Pathway Reactive oxygen species degradation
KEGG Pathway Peroxisome
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Prion diseases
NetPath Pathway TCR Signaling Pathway
Pathway Interaction Database Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor network
PathWhiz Pathway Degradation of Superoxides
Reactome Platelet degranulation
Detoxification of Reactive Oxygen Species
WikiPathways Oxidative Stress
Copper homeostasis
Detoxification of Reactive Oxygen Species
Nifedipine Activity
Amyotrophic lateral sclerosis (ALS)
Dopamine metabolism
AGE/RAGE pathway
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 523766ClinicalTrials.gov (NCT01513278) Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer. U.S. NationalInstitutes of Health.
Ref 525361Peyronie's disease: a critical appraisal of current diagnosis and treatment. Int J Impot Res. 2008 Sep-Oct;20(5):445-59. doi: 10.1038/ijir.2008.30. Epub 2008 Jul 24.

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