Drug General Information
Drug ID	D0HP1O
Drug Name	AF-DX-384
Synonyms	AF-DX-384; 118290-27-0; AF-DX-384
Drug Type	Small molecular drug
Indication	Unspecified		Investigative	[1560197], [1560396]
Structure		Download 2D MOL
Formula	C27H38N6O2
PubChem Compound ID	119357
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M4	Target Info	Modulator
	Muscarinic acetylcholine receptor M2	Target Info	Modulator
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, Other
References
Ref 1560197	M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site.
Ref 1560396	M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders.

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