Drug General Information
Drug ID	D0I0UW
Former ID	DNC010155
Drug Name	1-(4-p-Tolyl-butyl)-piperidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530299]
Structure		Download 2D MOL 3D MOL
Formula	C16H25N
Canonical SMILES	CC1=CC=C(C=C1)CCCCN2CCCCC2
InChI	1S/C16H25N/c1-15-8-10-16(11-9-15)7-3-6-14-17-12-4-2-5-13-17/h8-11H,2-7,12-14H2,1H3
InChIKey	ZJZNOPQUDXUEDU-UHFFFAOYSA-N
PubChem Compound ID	45485498
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Inhibitor	[530299]
	Potassium voltage-gated channel subfamily H member 2	Target Info	Inhibitor	[530299]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Histamine receptors
	G alpha (q) signalling eventsR-HSA-1296072:Voltage gated Potassium channels
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	Hematopoietic Stem Cell Differentiation
	Potassium Channels
References
Ref 530299	Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. Epub 2009 Aug 5.Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
Ref 530299	Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. Epub 2009 Aug 5.Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.

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