Drug General Information
Drug ID	D0I1AC
Former ID	DNC007632
Drug Name	(4-chloro-1H-pyrazol-1-yl)(o-tolyl)methanone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529037]
Structure		Download 2D MOL 3D MOL
Formula	C11H9ClN2O
Canonical SMILES	CC1=CC=CC=C1C(=O)N2C=C(C=N2)Cl
InChI	1S/C11H9ClN2O/c1-8-4-2-3-5-10(8)11(15)14-7-9(12)6-13-14/h2-7H,1H3
InChIKey	LBFRMVGIANQWAQ-UHFFFAOYSA-N
PubChem Compound ID	577102
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[529037]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosus
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.

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