| Drug General Information |
| Drug ID |
D0I3XA
|
| Former ID |
DNC002338
|
| Drug Name |
Ciproxifan
|
| Drug Type |
Small molecular drug
|
| Indication |
Dementia; Obesity [ICD9: 290-294, 278; ICD10:F01-F07, E66]
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H18N2O2
|
| InChI |
InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)
|
| InChIKey |
ACQBHJXEAYTHCY-UHFFFAOYSA-N
|
| CAS Number |
CAS 184025-19-2
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14774960, 29217532, 29217533, 43016263, 47434879, 47583760, 50070539, 50071174, 52113953, 53790071, 57298923, 57304380, 57366836, 85209025, 90341100, 103177393, 114520252, 123051072, 127387036, 131549292, 135323023, 135650102, 137007869, 137156933, 144235387, 152258581, 160647417, 162205198, 163641900, 177749578, 186014464, 189024876, 198972741, 198993150, 225089285, 229360424, 242060244, 249979315, 251883549
|
| Target and Pathway |
| Target(s) |
Alpha-2A adrenergic receptor |
Target Info |
Antagonist |
[2]
|
|---|
| 5-Hydroxytryptamine 3 receptor |
Target Info |
Antagonist |
[2]
|
| Histamine H3 receptor |
Target Info |
Antagonist |
[2]
|
| Alpha-2C adrenergic receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Reactome
|
Adrenoceptors
|
|
Adrenaline signalling through Alpha-2 adrenergic receptor
|
|
Adrenaline,noradrenaline inhibits insulin secretion
|
|
G alpha (i) signalling events
|
|
G alpha (z) signalling events
|
|
Surfactant metabolismR-HSA-390650:Histamine receptors
|
|
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
|
|
Surfactant metabolism
|
|
WikiPathways
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Platelet Aggregation (Plug Formation)
|
|
Integration of energy metabolism
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP727:Monoamine Transport
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1265). |
|---|
| REF 2 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. |
|---|
