Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I6IU
|
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| Former ID |
DIB007307
|
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| Drug Name |
SC-41930
|
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| Synonyms |
CGS-24115
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| Drug Type |
Small molecular drug
|
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| Indication | Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] | Discontinued in Phase 2 | [1], [2] | ||
| Company |
Intarcia Therapeutics.
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C28H36O7
|
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| InChI |
InChI=1S/C28H36O7/c1-5-8-21-23(13-10-19-11-14-25(28(30)31)35-26(19)21)33-16-7-17-34-24-15-12-20(18(3)29)27(32-4)22(24)9-6-2/h10,12-13,15,25H,5-9,11,14,16-17H2,1-4H3,(H,30,31)
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| InChIKey |
ZVVCSBSDFGYRCB-UHFFFAOYSA-N
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| CAS Number |
CAS 120072-59-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Leukotriene B4 receptor 1 | Target Info | Modulator | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| Reactome | Leukotriene receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6156). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001549) | ||||
| REF 3 | Multiple actions of the leukotriene B4 receptor antagonist SC-41930. J Pharmacol Exp Ther. 1992 Jan;260(1):187-91. | ||||
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