Drug General Information
Drug ID
D0I7MT
Former ID
DIB014224
Drug Name
Puerarin
Synonyms
NPI-031-G; Puerarin (oral formulation, alcoholism); Puerarin (oral formulation, alcoholism), Natural Pharmacia; 5-HT2creceptor antagonists/GABA receptor antagonists (oral formulation, alcoholism), Natural Pharmacia
Drug Type
Small molecular drug
Indication Alcohol use disorders [ICD9: 303; ICD10:F10.2] Phase 2 [522602]
Company
Natural Pharmacia International Inc
Structure
Download
2D MOL

3D MOL

Formula
C21H20O9
Canonical SMILES
c12c([C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)c(ccc1c<br />(=O)c(co2)c1ccc(cc1)O)O
PubChem Compound ID
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 522602ClinicalTrials.gov (NCT00854724) Puerarin Effects on Alcohol Drinking. U.S. National Institutes of Health.

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