Drug Information

Drug General Information
Drug ID
D0IE4H
Former ID
DIB003557
Drug Name
TAZOMELINE
Synonyms
Hexylthio-TZTP; LY-287041; Tazomeline < Prop INN; NNC-11-0309; 3-[3-(Hexylthio)-1,2,5-thiadiazol-4-yl]-1-methyl-1,2,5,6-tetrahydropyridine
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 1 [546138]
Structure
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2D MOL

3D MOL
Formula
C14H23N3S2
Canonical SMILES
CCCCCCSc1nsnc1C2=CCCN(C)C2
InChI
1S/C14H23N3S2/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
InChIKey
XUHMGFKQBWZWPO-UHFFFAOYSA-N
CAS Number
CAS 131987-54-7
PubChem Compound ID
131460
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Agonist [551871]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 546138Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006554)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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