Drug Information
Drug General Information | |||||
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Drug ID |
D0IP6X
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Former ID |
DCL000191
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Drug Name |
Osanetant
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Synonyms |
Osanetant [INN]; SB-236984; SR-14280; SR-142801; SR-142806; N-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-N-methylacetamide; N-(1-{3-[(3r)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl}-4-phenylpiperidin-4-yl)-n-methylacetamide; N-(1-(3-((3R)-1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl)propyl)-4-phenyl-4-piperidinyl)-N-methylacetamide; N-(1-(3-((R)-1-Benzoyl-3-(3,4-dichlorophenyl)-3-piperidyl)propyl)-4-phenyl-4-piperidyl)-N-methylacetamide
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Drug Type |
Small molecular drug
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Company |
Sanofi-aventis
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Structure |
Download2D MOL |
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Formula |
C35H41Cl2N3O2
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InChI |
InChI=1S/C35H41Cl2N3O2/c1-27(41)38(2)35(29-13-7-4-8-14-29)19-23-39(24-20-35)21-9-17-34(30-15-16-31(36)32(37)25-30)18-10-22-40(26-34)33(42)28-11-5-3-6-12-28/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3/t34-/m0/s1
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InChIKey |
DZOJBGLFWINFBF-UMSFTDKQSA-N
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CAS Number |
CAS 160492-56-8
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PubChem Compound ID | |||||
PubChem Substance ID |
9374273, 14765045, 14789447, 30422444, 47583780, 48329110, 50068883, 50070629, 50182021, 57304375, 57399839, 85286118, 90342450, 103399782, 103831276, 104132813, 113468548, 117463754, 126671662, 127809701, 134338860, 135650780, 137265093, 137275954, 141237279, 144116320, 152035367, 164780141, 175426879, 178100471, 198978083, 223660710, 223704871, 226491182, 252160228
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Target and Pathway | |||||
Target(s) | Nigral tachykinin NK(3) receptor | Target Info | Antagonist | [536865], [536894], [537495] | |
Reactome | G alpha (q) signalling events | ||||
References | |||||
Ref 536463 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. | ||||
Ref 539337 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2110). | ||||
Ref 536865 | Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412). Neuropharmacology. 2009 Feb;56(2):342-9. Epub 2008 Sep 18. | ||||
Ref 536894 | The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. Epub 2008 Oct 10. | ||||
Ref 537495 | Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2009 Jun 21. |
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