TTD | Drug: D0IW0Y

Drug General Information
Drug ID	D0IW0Y
Former ID	DIB002190
Drug Name	MEN-10207
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[545551]
Company	The Menarini Group
Structure		Download 2D MOL 3D MOL
Formula	C57H68N14O10
Canonical SMILES	C(=O)(N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N)CCCNC(=N)<br />N)Cc1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2)[C@@H](NC(=O)[C@H<br />](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)Cc1ccc(cc1)O)Cc1c[<br />nH]c2c1cccc2)C(C)C
CAS Number	CAS 126050-12-2
PubChem Compound ID	25079030
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Modulator	[528181]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545551	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003687)
Ref 528181	Role of D-tryptophan for affinity of MEN 10207 tachykinin antagonist at NK2 receptors. Peptides. 1991 Sep-Oct;12(5):1015-8.

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Drug Information