Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0IW0Y
|
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| Former ID |
DIB002190
|
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| Drug Name |
MEN-10207
|
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Terminated | [1] | ||
| Company |
The Menarini Group
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C57H68N14O10
|
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| Canonical SMILES |
C(=O)(N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N)CCCNC(=N)<br />N)Cc1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2)[C@@H](NC(=O)[C@H<br />](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)Cc1ccc(cc1)O)Cc1c[<br />nH]c2c1cccc2)C(C)C
|
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| CAS Number |
CAS 126050-12-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | NK-2 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003687) | ||||
| REF 2 | Role of D-tryptophan for affinity of MEN 10207 tachykinin antagonist at NK2 receptors. Peptides. 1991 Sep-Oct;12(5):1015-8. | ||||
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