Drug Information

Drug General Information
Drug ID
D0IX1A
Former ID
DAP001144
Drug Name
Pentolinium
Synonyms
Pentolineum; Pentolonium; Pentolonum; 1,1'-pentane-1,5-diylbis(1-methylpyrrolidinium); 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
Drug Type
Small molecular drug
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Approved [550664]
Therapeutic Class
Antihypertensive Agents
Company
Wyeth Ayerst Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C15H32N2+2
Canonical SMILES
C[N+]1(CCCC1)CCCCC[N+]2(CCCC2)C
InChI
1S/C15H32N2/c1-16(12-6-7-13-16)10-4-3-5-11-17(2)14-8-9-15-17/h3-15H2,1-2H3/q+2
InChIKey
XSBSKEQEUFOSDD-UHFFFAOYSA-N
CAS Number
CAS 52-62-0
PubChem Compound ID
5850
PubChem Substance ID
6341731, 8153614, 12088023, 15220920, 29224879, 46507977, 49698987, 50064427, 50143700, 57322996, 85539164, 103091740, 103152027, 103393615, 104310430, 117392668, 124750076, 129732921, 134338389, 135119893, 137009740, 139836973, 160964424, 163112542, 177748218, 179038968, 198953613, 226565096
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-4 chain Target Info Antagonist [537945]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic Neurons
References
Ref 550664Drug information of Pentolinium, 2008. eduDrugs.
Ref 537945Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203(3):372-6.

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