Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J0JC
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| Former ID |
DIB001121
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| Drug Name |
FRG-8701
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| Drug Type |
Small molecular drug
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| Indication | Stomach ulcer [ICD10:K25-K27] | Terminated | [1] | ||
| Company |
Fujirebio KK
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H30N2O4S
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| Canonical SMILES |
S(=O)(CC(=O)NCCCOc1cc(CN2CCCCC2)ccc1)Cc1occc1
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| CAS Number |
CAS 108498-50-6
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85. | ||||
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