Drug General Information
Drug ID	D0J0JC
Former ID	DIB001121
Drug Name	FRG-8701
Drug Type	Small molecular drug
Indication	Stomach ulcer [ICD10:K25-K27]		Terminated	[530445]
Company	Fujirebio KK
Structure		Download 2D MOL 3D MOL
Formula	C22H30N2O4S
Canonical SMILES	S(=O)(CC(=O)NCCCOc1cc(CN2CCCCC2)ccc1)Cc1occc1
CAS Number	CAS 108498-50-6
PubChem Compound ID	130145
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Modulator	[530445]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 530445	Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85.
Ref 530445	Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85.

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