Drug Information
Drug General Information | |||||
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Drug ID |
D0J0JC
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Former ID |
DIB001121
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Drug Name |
FRG-8701
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Drug Type |
Small molecular drug
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Indication | Stomach ulcer [ICD10:K25-K27] | Terminated | [1] | ||
Company |
Fujirebio KK
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Structure |
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Download2D MOL |
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Formula |
C22H30N2O4S
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Canonical SMILES |
S(=O)(CC(=O)NCCCOc1cc(CN2CCCCC2)ccc1)Cc1occc1
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CAS Number |
CAS 108498-50-6
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H2 receptor | Target Info | Modulator | [1] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gastric acid secretion | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Histamine H2 receptor mediated signaling pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
Gastric Acid Production | |||||
Reactome | Histamine receptors | ||||
G alpha (s) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85. | ||||
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