Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J0ZQ
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| Former ID |
DIB009751
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| Drug Name |
Nociceptin/orphanin FQ receptor PET ligands
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| Synonyms |
NOP receptor radioligands (neuropsychiatric disorders), Eli Lilly; Nociceptin/orphanin FQ receptor PET ligands (neuropsychiatric disorders); Nociceptin/orphanin FQ receptor PET ligands (neuropsychiatric disorders), Eli Lilly; 11C-NOP-1A
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| Indication | Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] | Investigative | [1] | ||
| Company |
Eli Lilly & Co
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C12(CCN(CC1)C[C@@H](C(=O)N[11CH3])Cc1ccccc1F)OCCc1c2sc(<br />c1)F
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| Target and Pathway | |||||
| Target(s) | Nociceptin receptor | Target Info | Binder | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). | ||||
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