Drug General Information
Drug ID	D0J1AE
Former ID	DNC011578
Drug Name	Phenethyl-(4-phenyl-butyl)-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534696]
Structure		Download 2D MOL 3D MOL
Formula	C18H23N
Canonical SMILES	C1=CC=C(C=C1)CCCCNCCC2=CC=CC=C2
InChI	1S/C18H23N/c1-3-9-17(10-4-1)13-7-8-15-19-16-14-18-11-5-2-6-12-18/h1-6,9-12,19H,7-8,13-16H2
InChIKey	HMGFNEMDDFFJES-UHFFFAOYSA-N
PubChem Compound ID	10708590
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[534696]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[534696]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Calcium signaling pathway
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers Disease
References
Ref 534696	J Med Chem. 1998 Aug 27;41(18):3499-506.Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.
Ref 534696	J Med Chem. 1998 Aug 27;41(18):3499-506.Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.

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