Drug Information

Drug General Information
Drug ID
D0J2UA
Former ID
DNC009448
Drug Name
6-bromoaplysinopsin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526321]
Structure
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2D MOL

3D MOL
Formula
C14H13BrN4O
Canonical SMILES
CN1C(=CC2=CNC3=C2C=CC(=C3)Br)C(=O)N(C1=N)C
InChI
1S/C14H13BrN4O/c1-18-12(13(20)19(2)14(18)16)5-8-7-17-11-6-9(15)3-4-10(8)11/h3-7,16-17H,1-2H3/b12-5+,16-14?
InChIKey
OVVZEMAUZWSOHR-ZSUDRMHPSA-N
PubChem Compound ID
10404564
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [526321]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [526321]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 526321J Nat Prod. 2002 Apr;65(4):476-80.New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.
Ref 526321J Nat Prod. 2002 Apr;65(4):476-80.New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.

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