TTD | Drug: D0J2YB

Drug General Information
Drug ID	D0J2YB
Former ID	DIB021242
Drug Name	YIL781
Synonyms	YIL-781; YIL 781
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540470]
Structure		Download 2D MOL
Formula	C24H28FN3O2
InChI	InChI=1S/C24H28FN3O2/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3/t18-/m0/s1
InChIKey	FRKXOBMDEXCHHD-SFHVURJKSA-N
PubChem Compound ID	23631116
PubChem Substance ID	46492603, 56018966, 103527490, 104095101, 141137819, 178100517, 228826692, 247821176
Target and Pathway
Target(s)	Growth hormone secretagogue receptor type 1	Target Info	Antagonist	[528960]
KEGG Pathway	cAMP signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	Leptin Signaling Pathway
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540470	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3538).
Ref 528960	Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology. 2007 Nov;148(11):5175-85. Epub 2007 Jul 26.

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Drug Information