Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J3QU
|
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| Former ID |
DIB001817
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| Drug Name |
ZD-7944
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| Drug Type |
Small molecular drug
|
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| Indication | Asthma [ICD10:J45] | Terminated | [1] | ||
| Company |
Zeneca Group plc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C31H34Cl2N2O2S
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| Canonical SMILES |
C(=O)(N(C[C@H](c1cc(c(cc1)Cl)Cl)CCN1CCC(c2c(S(=O)C)cccc<br />2)CC1)C)c1ccccc1.Cl
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| CAS Number |
CAS 161609-55-8
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | NK-2 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007349) | ||||
| REF 2 | Discovery of novel, orally active dual NK1/NK2 antagonists. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2769-73. | ||||
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