Drug Information

Drug General Information
Drug ID
D0J3TY
Former ID
DNC007579
Drug Name
2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528969]
Structure
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2D MOL

3D MOL
Formula
C17H13N3O
Canonical SMILES
CC1=CC(=CC=C1)N2C=C3C4=CC=CC=C4NC(=O)C3=N2
InChI
1S/C17H13N3O/c1-11-5-4-6-12(9-11)20-10-14-13-7-2-3-8-15(13)18-17(21)16(14)19-20/h2-10H,1H3,(H,18,21)
InChIKey
KHYUWCCULSYNJP-UHFFFAOYSA-N
PubChem Compound ID
10588437
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [528969]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 528969J Med Chem. 2007 Aug 23;50(17):4061-74. Epub 2007 Aug 1.New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Ref 528969J Med Chem. 2007 Aug 23;50(17):4061-74. Epub 2007 Aug 1.New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.

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