Drug Information

Drug General Information
Drug ID
D0J3VX
Former ID
DNC007545
Drug Name
1-(isoquinolin-5-yl)-3-(4-morpholinobenzyl)urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528909]
Structure
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2D MOL

3D MOL
Formula
C21H22N4O2
Canonical SMILES
C1COCCN1C2=CC=C(C=C2)CNC(=O)NC3=CC=CC4=C3C=CN=C4
InChI
1S/C21H22N4O2/c26-21(24-20-3-1-2-17-15-22-9-8-19(17)20)23-14-16-4-6-18(7-5-16)25-10-12-27-13-11-25/h1-9,15H,10-14H2,(H2,23,24,26)
InChIKey
LAJBRLBYOVKUOY-UHFFFAOYSA-N
PubChem Compound ID
10248092
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Inhibitor [528909]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 528909J Med Chem. 2007 Jul 26;50(15):3651-60. Epub 2007 Jun 21.In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.
Ref 528909J Med Chem. 2007 Jul 26;50(15):3651-60. Epub 2007 Jun 21.In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.

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