Drug General Information |
Drug ID |
D0J4ON
|
Former ID |
DIB019091
|
Drug Name |
RGB-286147
|
Synonyms |
pyrazolopyrimidone analog, RGB-286147
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C23H22Cl2N4O3
|
InChI |
InChI=1S/C23H22Cl2N4O3/c1-13(2)20-19-22(29(28-20)21-16(24)4-3-5-17(21)25)26-18(27-23(19)31)12-14-6-8-15(9-7-14)32-11-10-30/h3-9,13,28,30H,10-12H2,1-2H3
|
InChIKey |
VQNCIRRXQQTXEL-UHFFFAOYSA-N
|
PubChem Compound ID |
|
PubChem Substance ID |
14720368, 26758448, 44692630, 52995877, 99302688, 103567255, 125082193, 137892323, 163126201, 163688388, 174007036, 175607469, 178102566, 180371694, 227415676, 244731021
|
Target and Pathway |
Target(s) |
Cell division protein kinase 7 |
Target Info |
Inhibitor |
[2]
|
Cell division protein kinase 6 |
Target Info |
Inhibitor |
[2]
|
Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
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Basal transcription factors
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Nucleotide excision repair
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Cell cyclehsa04110:Cell cycle
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Hepatitis B
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Measles
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Pathways in cancer
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Viral carcinogenesis
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MicroRNAs in cancer
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Pancreatic cancer
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Glioma
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Melanoma
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Chronic myeloid leukemia
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Small cell lung cancer
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Non-small cell lung cancerhsa04012:ErbB signaling pathway
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Chemokine signaling pathway
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Cell cycle
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Wnt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Focal adhesion
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Signaling pathways regulating pluripotency of stem cells
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Neurotrophin signaling pathway
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Dopaminergic synapse
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Insulin signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
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Hepatitis C
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Influenza A
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HTLV-I infection
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Epstein-Barr virus infection
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Colorectal cancer
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Endometrial cancer
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Prostate cancer
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Basal cell carcinoma
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NetPath Pathway
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TCR Signaling Pathway
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RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-presenilin pathway
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Angiogenesis
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Cadherin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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Ras Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Retinoic acid receptors-mediated signalingp73pathway:p73 transcription factor network
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Coregulation of Androgen receptor activity
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C-MYB transcription factor network
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IL2 signaling events mediated by STAT5
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Regulation of retinoblastoma proteinlysophospholipid_pathway:LPA receptor mediated events
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Degradation of beta catenin
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Reelin signaling pathway
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Presenilin action in Notch and Wnt signaling
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Integrin-linked kinase signaling
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CDC42 signaling events
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LKB1 signaling events
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Canonical Wnt signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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C-MYC pathway
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Regulation of Androgen receptor activity
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Validated transcriptional targets of deltaNp63 isoforms
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Aurora A signaling
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Insulin-mediated glucose transport
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Class I PI3K signaling events mediated by Akt
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p53 pathway
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Trk receptor signaling mediated by PI3K and PLC-gamma
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Reactome
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NoRC negatively regulates rRNA expression
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Formation of TC-NER Pre-Incision Complex
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Dual incision in TC-NER
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Gap-filling DNA repair synthesis and ligation in TC-NER
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Cyclin E associated events during G1/S transition
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Cyclin D associated events in G1
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Cyclin A/B1 associated events during G2/M transition
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Cyclin A:Cdk2-associated events at S phase entry
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RNA Polymerase I Transcription InitiationR-HSA-2559580:Oxidative Stress Induced Senescence
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Senescence-Associated Secretory Phenotype (SASP)
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Oncogene Induced Senescence
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Cyclin D associated events in G1R-HSA-195253:Degradation of beta-catenin by the destruction complex
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AKT phosphorylates targets in the cytosol
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Regulation of HSF1-mediated heat shock response
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CRMPs in Sema3A signaling
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
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S33 mutants of beta-catenin aren't phosphorylated
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S37 mutants of beta-catenin aren't phosphorylated
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S45 mutants of beta-catenin aren't phosphorylated
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T41 mutants of beta-catenin aren't phosphorylated
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Degradation of GLI2 by the proteasome
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Constitutive Signaling by AKT1 E17K in Cancer
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WikiPathways
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G1 to S cell cycle control
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Eukaryotic Transcription Initiation
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Cardiac Hypertrophic Response
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S Phase
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HIV Life Cycle
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Integrated Breast Cancer Pathway
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Nucleotide Excision Repair
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RNA Polymerase II Transcription
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
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mRNA Capping
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Mitotic G2-G2/M phases
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Mitotic G1-G1/S phases
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MicroRNAs in cardiomyocyte hypertrophyWP707:DNA Damage Response
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Wnt Signaling Pathway Netpath
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Retinoblastoma (RB) in Cancer
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Signaling Pathways in Glioblastoma
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Metastatic brain tumor
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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Cell Cycle
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miRNAs involved in DNA damage response
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miRNA Regulation of DNA Damage ResponseWP710:DNA Damage Response (only ATM dependent)
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Senescence and Autophagy in Cancer
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Notch Signaling Pathway
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Glycogen Metabolism
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Insulin Signaling
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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IL-6 signaling pathway
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Copper homeostasis
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Focal Adhesion
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Hair Follicle Development: Induction (Part 1 of 3)
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Degradation of beta-catenin by the destruction complex
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T-Cell Receptor and Co-stimulatory Signaling
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Cardiac Progenitor Differentiation
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BDNF signaling pathway
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Corticotropin-releasing hormone
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B Cell Receptor Signaling Pathway
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IL17 signaling pathway
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Neural Crest Differentiation
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Alzheimers Disease
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IL-7 Signaling Pathway
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Regulation of Microtubule Cytoskeleton
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TWEAK Signaling Pathway
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Leptin signaling pathway
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Semaphorin interactions
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MicroRNAs in cardiomyocyte hypertrophy
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Androgen receptor signaling pathway
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IL-5 Signaling Pathway
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References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5943). |
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REF 2 | Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |