| Drug General Information |
| Drug ID |
D0J6JT
|
| Former ID |
DIB020312
|
| Drug Name |
m-chlorophenylpiperazine
|
| Synonyms |
1-(m-chlorophenyl)piperazine; meta chlorophenyl piperazine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C10H13ClN2
|
| InChI |
InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
|
| InChIKey |
VHFVKMTVMIZMIK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
13903, 101536, 3134490, 5654977, 8151106, 11110958, 11113750, 15487730, 24439696, 26744257, 26751928, 29200406, 32928407, 47440463, 47959960, 47959961, 48110652, 48334707, 50008640, 50104608, 53788779, 53792953, 57320881, 57566619, 58033993, 79793345, 85208880, 85261770, 85788310, 87631290, 92091370, 92712037, 103169070, 103904029, 103916282, 104171132, 104297497, 104649718, 117458520, 118082316, 124749567, 124879663, 124879664, 124879665, 125323619, 125355774, 126581139, 126607690, 126614717, 126630282
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1E receptor |
Target Info |
Agonist |
[2]
|
|---|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Agonist |
[3]
|
| 5-hydroxytryptamine 7 receptor |
Target Info |
Agonist |
[4]
|
| 5-hydroxytryptamine 6 receptor |
Target Info |
Agonist |
[5]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Agonist |
[6]
|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Agonist |
[7]
|
| 5-hydroxytryptamine 1D receptor |
Target Info |
Antagonist |
[8]
|
|
KEGG Pathway
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Gap junction
|
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Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04014:Ras signaling pathway
|
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Calcium signaling pathway
|
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
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Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathway
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PathWhiz Pathway
|
Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
|
|
Reactome
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Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling events
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
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GPCR downstream signaling
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GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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SIDS Susceptibility Pathways
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GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 142). |
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| REF 2 | Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. |
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| REF 3 | Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. Eur J Pharmacol. 2004 Jan 1;483(1):37-43. |
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| REF 4 | Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem. 1993 Aug 25;268(24):18200-4. |
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| REF 5 | Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. |
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| REF 6 | Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6. |
|---|
| REF 7 | Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. |
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| REF 8 | Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8. |
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