Drug Information

Drug General Information
Drug ID
D0J7EM
Former ID
DNC008104
Drug Name
1-phenylthio-N,N-dimethyltryptamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529258]
Structure
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2D MOL

3D MOL
Formula
C18H20N2S
Canonical SMILES
CN(C)CCC1=CN(C2=CC=CC=C21)SC3=CC=CC=C3
InChI
1S/C18H20N2S/c1-19(2)13-12-15-14-20(18-11-7-6-10-17(15)18)21-16-8-4-3-5-9-16/h3-11,14H,12-13H2,1-2H3
InChIKey
APYJLIWKKMRCGM-UHFFFAOYSA-N
PubChem Compound ID
24776941
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [529258]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529258J Med Chem. 2008 Feb 14;51(3):603-11. Epub 2008 Jan 18.Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.
Ref 529258J Med Chem. 2008 Feb 14;51(3):603-11. Epub 2008 Jan 18.Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

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