Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J7GF
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| Former ID |
DNC011964
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| Drug Name |
Benzyl-(2-phenyl-quinazolin-4-yl)-amine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [533684] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C21H17N3
|
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| Canonical SMILES |
C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4
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| InChI |
1S/C21H17N3/c1-3-9-16(10-4-1)15-22-21-18-13-7-8-14-19(18)23-20(24-21)17-11-5-2-6-12-17/h1-14H,15H2,(H,22,23,24)
|
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| InChIKey |
WXCHSHPXEPXKFN-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | CAMP-specific 3',5'-cyclic phosphodiesterase 4B | Target Info | Inhibitor | [533684] | |
| Sodium-dependent dopamine transporter | Target Info | Inhibitor | [535513] | ||
| CAMP-specific 3',5'-cyclic phosphodiesterase 4A | Target Info | Inhibitor | [533684] | ||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| WikiPathways | G Protein Signaling Pathways | ||||
| Myometrial Relaxation and Contraction Pathways | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Opioid SignallingWP727:Monoamine Transport | |||||
| NRF2 pathway | |||||
| Dopaminergic Neurogenesis | |||||
| Parkinsons Disease Pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| Neurotransmitter Clearance In The Synaptic CleftWP35:G Protein Signaling Pathways | |||||
| References | |||||
| Ref 533684 | J Med Chem. 1995 Sep 1;38(18):3547-57.Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities. | ||||
| Ref 535513 | Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8. | ||||
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