Drug Information

Drug General Information
Drug ID
D0JT3M
Former ID
DNC005277
Drug Name
[2-(3-Benzyl-indol-1-yl)-ethyl]-dimethyl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527501]
Structure
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2D MOL

3D MOL
Formula
C19H22N2
Canonical SMILES
CN(C)CCN1C=C(C2=CC=CC=C21)CC3=CC=CC=C3
InChI
1S/C19H22N2/c1-20(2)12-13-21-15-17(14-16-8-4-3-5-9-16)18-10-6-7-11-19(18)21/h3-11,15H,12-14H2,1-2H3
InChIKey
OYHBRXFQPGMFDE-UHFFFAOYSA-N
PubChem Compound ID
20722800
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527501]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527501Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors.
Ref 527501Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors.

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