Drug General Information
Drug ID
D0JY2K
Former ID
DIB014038
Drug Name
NS-1643
Synonyms
HERG potassium channel openers (arrhythmia); NS-1643; NS-3623; NS-373; HERG potassium channel openers (arrhythmia), NeuroSearch; I(Kr) agonists (arrhythmia), NeuroSearch; Rapid delayed-rectifier current activators (acquired long QT syndrome), NeruoSearch
Drug Type
Small molecular drug
Indication Heart arrhythmia [ICD10:I47-I49] Investigative [542638]
Company
NeuroSearch A/S
Structure
Download
2D MOL

3D MOL

Formula
C15H10F6N2O3
InChI
InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
InChIKey
NJFVQMRYJZHGME-UHFFFAOYSA-N
CAS Number
CAS 343630-41-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Opener [543879]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 542638(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7660).
Ref 543879(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 572).

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