Drug Information

Drug General Information
Drug ID
D0K1QS
Former ID
DNC002827
Drug Name
Dimethyltryptamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538886]
Structure
Download
2D MOL

3D MOL
Formula
C12H16N2
InChI
InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
InChIKey
DMULVCHRPCFFGV-UHFFFAOYSA-N
CAS Number
CAS 61-50-7
PubChem Compound ID
6089
PubChem Substance ID
10500, 110132, 589970, 627611, 5091638, 7980056, 8153806, 10529872, 15265804, 29225098, 46507463, 46530476, 49747346, 49983960, 50909762, 57323178, 58007473, 85209948, 94526579, 99381451, 103172928, 103936452, 104311088, 124954094, 125655143, 126525562, 126552446, 126660419, 126687274, 127757321, 131728744, 134350860, 134971030, 135650188, 137001252, 142148247, 160964744, 162881661, 164840499, 170538817, 179226219, 196397667, 198948879, 223675963, 223978815, 226671707, 244002216, 249781217, 249924405, 252157284
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Inhibitor [551401]
5-hydroxytryptamine 6 receptor Target Info Inhibitor [551401]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [551401]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBaseWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, Other
References
Ref 538886(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 141).
Ref 551401Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects. Arch Gen Psychiatry. 1994 Feb;51(2):85-97.

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