Drug Information

Drug General Information
Drug ID
D0K2XD
Former ID
DIB018760
Drug Name
ADX71743
Synonyms
ADX 71743; ADX-71743
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541386]
Structure
Download
2D MOL
Formula
C17H19NO2
InChI
InChI=1S/C17H19NO2/c1-4-16-18-17-14(19)8-12(9-15(17)20-16)13-6-5-10(2)7-11(13)3/h5-7,12H,4,8-9H2,1-3H3
InChIKey
CPKZCQHJDFSOJT-UHFFFAOYSA-N
PubChem Compound ID
53391766
PubChem Substance ID
125320001, 178102838
Target and Pathway
Target(s) Metabotropic glutamate receptor 7 Target Info Modulator (allosteric modulator) [532163]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541386(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6217).
Ref 532163ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.

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