Drug General Information
Drug ID
D0K4MG
Former ID
DNC009463
Drug Name
2-HYDROXYGARVIN A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528499]
Structure
Download
2D MOL

3D MOL

Formula
C23H26O7
Canonical SMILES
CCCC1=C(C(=CC2=CC3=C(C(=C21)O)C(=O)C(C(=O)C3(C)C)(C)O)O<br />C)C(=O)OC
InChI
1S/C23H26O7/c1-7-8-12-15-11(10-14(29-5)16(12)20(26)30-6)9-13-17(18(15)24)19(25)23(4,28)21(27)22(13,2)3/h9-10,24,28H,7-8H2,1-6H3
InChIKey
PRAZMVBMBFPZFN-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [528499]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 528499J Nat Prod. 2006 Oct;69(10):1496-9.Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.
Ref 528499J Nat Prod. 2006 Oct;69(10):1496-9.Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

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