Drug Information

Drug General Information
Drug ID
D0K5RX
Former ID
DNC004980
Drug Name
KYS-05050
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [528495]
Structure
Download
2D MOL

3D MOL
Formula
C34H37N5O
Canonical SMILES
C1=CC=C(C=C1)CNC(=O)CC2C3=CC=CC=C3N=C(N2C4=CC=C(C=C4)C5<br />=CC=CC=C5)NCCCCCN
InChI
1S/C34H37N5O/c35-22-10-3-11-23-36-34-38-31-17-9-8-16-30(31)32(24-33(40)37-25-26-12-4-1-5-13-26)39(34)29-20-18-28(19-21-29)27-14-6-2-7-15-27/h1-2,4-9,12-21,32H,3,10-11,22-25,35H2,(H,36,38)(H,37,40)
InChIKey
PHOBNPDRNIKURV-UHFFFAOYSA-N
PubChem Compound ID
16048645
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Inhibitor [528495]
Voltage-dependent T-type calcium channel alpha-1G subunit Target Info Inhibitor [528495]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainmenthsa04010:MAPK signaling pathway
Circadian entrainment
Type II diabetes mellitus
PANTHER Pathway Endogenous cannabinoid signaling
GABA-B receptor II signaling
Nicotine pharmacodynamics pathway
Pathway Interaction Database Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome NCAM1 interactionsR-HSA-419037:NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growthWP1866:NCAM signaling for neurite out-growth
Nicotine Activity on Chromaffin Cells
References
Ref 528495Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. Epub 2006 Oct 12.Synthesis and biological evaluation of novel T-type calcium channel blockers.
Ref 528495Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. Epub 2006 Oct 12.Synthesis and biological evaluation of novel T-type calcium channel blockers.

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