Drug Information

Drug General Information
Drug ID
D0KD1U
Former ID
DAP000940
Drug Name
Practolol
Synonyms
Dalzic; Eraldin; Practololo; Practololum; Praktololu; Teranol; Eralzdin Practolol; Practololo [DCIT]; Praktololu [Polish]; AY 21011; Cardiol (TN); Cordialina (TN); Dalzic (TN); Eraldin (TN); Eraldina (TN); Practololum [INN-Latin]; Praktol (TN); Pralon (TN); Teranol (TN); Practolol [USAN:BAN:INN]; N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide; N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide; N-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide; N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide; N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide; (+-)-Practolol; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide
Drug Type
Small molecular drug
Indication Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49] Approved [535807], [540932]
Therapeutic Class
Antiarrhythmic Agents
Structure
Download
2D MOL

3D MOL
Formula
C14H22N2O3
InChI
InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
InChIKey
DURULFYMVIFBIR-UHFFFAOYSA-N
CAS Number
CAS 6673-35-4
PubChem Compound ID
4883
PubChem Substance ID
13861, 4500647, 7979385, 8150016, 8153002, 10321694, 11336076, 11361315, 11364348, 11366910, 11369472, 11374635, 11377634, 11462287, 11466360, 11467480, 11485240, 11486020, 11489388, 11492674, 11495268, 15197223, 26679880, 26751910, 26980600, 29223962, 46507496, 47207250, 47440331, 47959823, 48185058, 48259303, 48334570, 48334571, 48334572, 48414361, 49698824, 49860734, 50104588, 56413037, 56463034, 57322502, 80701653, 85209244, 85451356, 85788851, 87660772, 92125329, 92308845, 99301989
SuperDrug ATC ID
C07AB01
SuperDrug CAS ID
cas=006673354
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [535324], [535807]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 535807Prostaglandin E2 synthesis elicited by adrenergic stimuli in guinea pig trachea is mediated primarily via activation of beta 2 adrenergic receptors. Prostaglandins. 1992 Nov;44(5):399-412.
Ref 540932(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 555).
Ref 535324TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
Ref 535807Prostaglandin E2 synthesis elicited by adrenergic stimuli in guinea pig trachea is mediated primarily via activation of beta 2 adrenergic receptors. Prostaglandins. 1992 Nov;44(5):399-412.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.