Drug Information

Drug General Information
Drug ID
D0KX1E
Former ID
DIB003893
Drug Name
CEP-2563
Synonyms
KT-8391; L-Lysyl-beta-alanine 9(S),12(R)-Epoxy-10(S)-methoxy-9-methyl-1-oxo-2,3,9,10,11,12-hexahydro-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-10-ylmethyl ester dihydrochloride
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 1 [546416]
CAS Number
CAS 183488-70-2
Target and Pathway
Target(s) Trk receptor Target Info Modulator [527155]
Beta platelet-derived growth factor receptor Target Info Inhibitor [531635]
Alpha platelet-derived growth factor receptor Target Info Inhibitor [527155]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Endocytosis
Choline metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathway
Pathway Interaction Database Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling networkatf2_pathway:ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling network
Reactome ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activationR-HSA-1257604:PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
RAF/MAP kinase cascade
WikiPathways MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membraneWP51:Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
PIP3 activates AKT signaling
PDGF Pathway
Signaling Pathways in Glioblastoma
Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
Hair Follicle Development: Organogenesis (Part 2 of 3)
Cardiac Progenitor Differentiation
Allograft Rejection
Signaling by PDGF
Angiogenesis
References
Ref 546416Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007988)
Ref 527155Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors. Invest New Drugs. 2004 Nov;22(4):449-58.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.

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