Drug Information

Drug General Information
Drug ID
D0L4VR
Former ID
DNC000388
Drug Name
Carbenoxolone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467496]
Structure
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2D MOL

3D MOL
Formula
C34H50O7
InChI
InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40)/t21-,23-,24-,27+,30+,31-,32-,33+,34+/m0/s1
InChIKey
OBZHEBDUNPOCJG-WBXJDKIVSA-N
CAS Number
CAS 79404-91-4
PubChem Compound ID
636403
PubChem Substance ID
7886488, 11068138, 11466865, 11467985, 11486450, 14764266, 16767811, 26706622, 43758895, 47291139, 47440262, 48035126, 48334500, 48415693, 51091924, 78326419, 85787318, 103059024, 103590439, 104102199, 113523857, 125311953, 134339830, 134987906, 137254896, 138569897, 152090780, 163875152, 178100972, 179230495, 198987908, 226455625, 250133956
SuperDrug ATC ID
A02BX01
SuperDrug CAS ID
cas=005697563
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [535911], [536921], [537302]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 467496(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4151).
Ref 535911Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. J Biol Chem. 2004 Apr 30;279(18):18415-24. Epub 2004 Feb 18.
Ref 536921Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart. Clin Sci (Lond). 2009 May;116(9):731-9.
Ref 537302Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid. J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):248-52. Epub 2009 Feb 7.

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