Drug Information

Drug General Information
Drug ID
D0L5JL
Former ID
DIB018702
Drug Name
8-cyclopentyltheophylline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540518]
Structure
Download
2D MOL
Formula
C12H16N4O2
InChI
InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)
InChIKey
SCVHFRLUNIOSGI-UHFFFAOYSA-N
PubChem Compound ID
1917
PubChem Substance ID
404613, 7422376, 7422378, 7978472, 8150162, 8151340, 11110875, 11335999, 11361238, 11363245, 11365807, 11368369, 11371615, 11374259, 11376531, 11454377, 11462210, 11485544, 11489550, 11490474, 11492575, 11494165, 14774253, 17404954, 24277730, 26613177, 26679778, 26747498, 26753550, 29221108, 46500409, 47440479, 47589040, 47736529, 47810975, 48110664, 48334539, 50050395, 50106161, 50106162, 53777497, 57321066, 59775498, 78695933, 85085052, 85208930, 85230945, 85789572, 90341471, 92303920
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [534757]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540518(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 385).
Ref 534757Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors. Biochem Pharmacol. 1998 Dec 1;56(11):1437-45.

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