Drug Information

Drug General Information
Drug ID
D0L5XI
Former ID
DCL000044
Drug Name
AMG-517
Synonyms
AMG 517; BD-0082
Drug Type
Small molecular drug
Indication Chronic pathological pain [ICD9: 338,780; ICD10:R52, G89] Discontinued in Phase 1 [1], [2]
Therapeutic Class
Analgesics
Company
Amgen
Structure
Download
2D MOL

3D MOL
Formula
C20H13F3N4O2S
InChI
InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)
InChIKey
YUTIXVXZQIQWGY-UHFFFAOYSA-N
PubChem Compound ID
16007367
PubChem Substance ID
24383515, 26579828, 37337787, 49688631, 93815005, 103521354, 125434268, 134338750, 139441965, 152133954, 163620713, 163686030, 163893972, 172650234, 178100951, 184819191, 187071894, 198971960, 223867499, 227292639, 242060343, 247809515, 248044101, 251962960, 252451728, 252470395
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker [3], [4]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
REF 1(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4129).
REF 2Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021804)
REF 3The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov. 2007 May;6(5):357-72.
REF 4Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. Epub 2009 Mar 5.

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