Drug General Information
Drug ID	D0L7RB
Former ID	DNC006145
Drug Name	1-(4-hydroxyphenyl)prop-2-en-1-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527869]
Structure		Download 2D MOL 3D MOL
Formula	C9H8O2
Canonical SMILES	C=CC(=O)C1=CC=C(C=C1)O
InChI	1S/C9H8O2/c1-2-9(11)7-3-5-8(10)6-4-7/h2-6,10H,1H2
InChIKey	NKPPNPJUBLEKAD-UHFFFAOYSA-N
PubChem Compound ID	16036927
Target and Pathway
Target(s)	4-aminobutyrate aminotransferase, mitochondrial	Target Info	Inhibitor	[527869]
	Succinate semialdehyde dehydrogenase, mitochondrial	Target Info	Inhibitor	[527869]
BioCyc Pathway	GABA shunt
	Valine degradation
	Beta-alanine degradation
	4-aminobutyrate degradationGLUDEG-I-PWY:GABA shunt
	4-aminobutyrate degradation
KEGG Pathway	Alanine, aspartate and glutamate metabolism
	Valine, leucine and isoleucine degradation
	beta-Alanine metabolism
	Propanoate metabolism
	Butanoate metabolism
	Metabolic pathways
	GABAergic synapsehsa00250:Alanine, aspartate and glutamate metabolism
PANTHER Pathway	Aminobutyrate degradation
	Pyrimidine Metabolism
	Gamma-aminobutyric acid synthesisP02726:Aminobutyrate degradation
	Gamma-aminobutyric acid synthesis
PathWhiz Pathway	Aspartate Metabolism
	Glutamate Metabolism
	Beta-Alanine Metabolism
	Valine, Leucine and Isoleucine Degradation
	Propanoate MetabolismPW000003:Glutamate Metabolism
WikiPathways	GABA synthesis, release, reuptake and degradation
	Alanine and aspartate metabolismWP2685:GABA synthesis, release, reuptake and degradation
References
Ref 527869	Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.
Ref 527869	Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. Epub 2005 Nov 14.Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.

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