Drug Information

Drug General Information
Drug ID
D0L7VL
Former ID
DNC007571
Drug Name
LIDOFLAZINE
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Approved [551871]
Structure
Download
2D MOL

3D MOL
Formula
C30H35F2N3O
Canonical SMILES
CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C<br />4=CC=C(C=C4)F
InChI
1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
InChIKey
ZBIAKUMOEKILTF-UHFFFAOYSA-N
CAS Number
CAS 3416-26-0
PubChem Compound ID
3926
SuperDrug ATC ID
C08EX01
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.3 Target Info Inhibitor [533974]
Equilibrative nucleoside transporter 1 Target Info Inhibitor [528952]
Sodium channel Target Info Inhibitor [533974]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and Ankyrins
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 528952J Med Chem. 2007 Aug 9;50(16):3906-20. Epub 2007 Jul 18.Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors.
Ref 533974J Med Chem. 1994 Jan 21;37(2):268-74.Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.

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