Drug General Information
Drug ID	D0L8KJ
Former ID	DIB002837
Drug Name	Oglemilast
Synonyms	GRC-3886; Oglemilast (oral, COPD/asthma), Glenmark
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Phase 2	[522312]
Company	Glenmark Pharmaceuticals Ltd
Structure		Download 2D MOL 3D MOL
Formula	C20H13Cl2F2N3O5S
Canonical SMILES	c1(ccc2c(c1)c1c(o2)c(ccc1C(=O)Nc1c(cncc1Cl)Cl)OC(F)F)NS<br />(=O)(=O)C
CAS Number	CAS 778576-62-8
PubChem Compound ID	11387409
Target and Pathway
Target(s)	CAMP-specific 3',5'-cyclic phosphodiesterase 4A	Target Info	Inhibitor	[544060]
	CAMP-specific 3',5'-cyclic phosphodiesterase 4B	Target Info	Inhibitor	[544060]
	Type IV phosphodiesterase	Target Info	Inhibitor	[544060]
KEGG Pathway	Purine metabolism
	cAMP signaling pathway
	Morphine addictionhsa00230:Purine metabolism
	Morphine addiction
NetPath Pathway	IL5 Signaling Pathway
	IL2 Signaling Pathway
PathWhiz Pathway	Purine Metabolism
Reactome	DARPP-32 events
	G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
	G alpha (s) signalling events
WikiPathways	G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Nuclear Receptors Meta-Pathway
	Opioid SignallingWP35:G Protein Signaling Pathways
	TSH signaling pathway
References
Ref 522312	ClinicalTrials.gov (NCT00671073) Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD). U.S. National Institutes of Health.
Ref 544060	Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?. Br J Pharmacol. 2008 October; 155(3): 288-290.

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