Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L8WT
|
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| Former ID |
DNC000924
|
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| Drug Name |
MEN13510
|
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| Drug Type |
Small molecular drug
|
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| Indication | Asthma [ICD10:J45] | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C21H23N5S
|
||||
| Canonical SMILES |
CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4
|
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| InChI |
1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)
|
||||
| InChIKey |
SNFYYXUGUBUECJ-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | NK-2 receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor. Eur J Pharmacol. 2005 Jun 1;516(2):104-11. | ||||
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