Drug Information

Drug General Information
Drug ID
D0LA4I
Former ID
DNC005670
Drug Name
4-(Indane-1-sulfonyl)-phenylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527501]
Structure
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2D MOL

3D MOL
Formula
C15H15NO2S
Canonical SMILES
C1CC2=CC=CC=C2C1S(=O)(=O)C3=CC=C(C=C3)N
InChI
1S/C15H15NO2S/c16-12-6-8-13(9-7-12)19(17,18)15-10-5-11-3-1-2-4-14(11)15/h1-4,6-9,15H,5,10,16H2
InChIKey
AJRGJBUDLAAWNT-UHFFFAOYSA-N
PubChem Compound ID
44401621
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527501]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527501Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors.
Ref 527501Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors.

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