Drug Information

Drug General Information
Drug ID
D0LH5P
Former ID
DNC011516
Drug Name
GNF-PF-173
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532648]
Structure
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2D MOL

3D MOL
Formula
C20H21N7O5
Canonical SMILES
C1=CC(=CC=C1CCC2=CN=C3C(=N2)C(=NC(=N3)N)N)C(=O)NC(CCC(=<br />O)O)C(=O)O
InChI
1S/C20H21N7O5/c21-16-15-17(27-20(22)26-16)23-9-12(24-15)6-3-10-1-4-11(5-2-10)18(30)25-13(19(31)32)7-8-14(28)29/h1-2,4-5,9,13H,3,6-8H2,(H,25,30)(H,28,29)(H,31,32)(H4,21,22,23,26,27)/t13-/m0/s1
InChIKey
LGFLRHWJJKLPCC-ZDUSSCGKSA-N
PubChem Compound ID
100516
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [532648]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 532648J Med Chem. 1988 Jan;31(1):181-5.Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
Ref 532648J Med Chem. 1988 Jan;31(1):181-5.Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.

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