Drug General Information
Drug ID	D0LJ0L
Former ID	DIB015250
Drug Name	Lu-AA47070
Synonyms	Adenosine A2a antagonists (Parkinson's disease), Lundbeck
Indication	Parkinson's disease [ICD9: 332; ICD10:G20]		Discontinued in Phase 1	[548653]
Company	H. Lundbeck A/S
Structure		Download 2D MOL 3D MOL
Canonical SMILES	P(=O)(OCn1/c(=N/C(=O)c2cc(c(c(c2)F)NC(=O)CC(C)(C)C)F)/s<br />cc1)(O)O
Target and Pathway
Target(s)	Adenosine A2a receptor	Target Info	Antagonist	[531680]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholism
Pathway Interaction Database	HIF-2-alpha transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	NGF-independant TRKA activation
	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	NGF signalling via TRKA from the plasma membrane
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 548653	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027391)
Ref 531680	The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505.

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