Drug General Information
Drug ID
D0LR1M
Former ID
DIB003495
Drug Name
LY-444711
Synonyms
2(R)-(2-Amino-2-methylpropanamido)-N-[1-[1(R)-(4-methoxyphenyl)-1-methyl-2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-imidazol-4-yl]-5-phenylpentanamide dihydrochloride
Indication Growth hormone deficiency [ICD9: 253.0, 253.3; ICD10:E22.0, E23.0] Discontinued in Phase 1 [547057]
Structure
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2D MOL

3D MOL

CAS Number
CAS 220541-10-6
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Agonist [527265]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 547057Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012573)
Ref 527265Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5873-6.

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