Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0LR8X
|
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| Former ID |
DIB020955
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| Drug Name |
SKF-83556
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| Synonyms |
SK-83566; SK&F-83566
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H18BrNO
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| InChI |
InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
|
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| InChIKey |
XFTVOHWWEQGXLS-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5491588, 7980611, 8151057, 14777543, 24439588, 26752220, 47365430, 47440497, 47662526, 48110696, 50065403, 57320838, 75926542, 85787620, 103331797, 103808619, 103923120, 104297173, 117388470, 126407033, 129682574, 134223457, 135080025, 135651055, 163209974, 172649051, 179236225, 179447836, 250072303, 252559241
|
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| Target and Pathway | |||||
| Target(s) | D(1B) dopamine receptor | Target Info | Antagonist | [2] | |
| Dopamine D1 receptor | Target Info | Antagonist | [2] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Dopaminergic synapsehsa04020:Calcium signaling pathway | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Morphine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Dopamine receptor mediated signaling pathwayP05912:Dopamine receptor mediated signaling pathway | ||||
| PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
| Reactome | Dopamine receptors | ||||
| G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors | |||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 944). | ||||
| REF 2 | Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. | ||||
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