Drug Information

Drug General Information
Drug ID
D0M0HJ
Former ID
DCL001120
Drug Name
S-18986
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Discontinued in Phase 2 [467644], [546269]
Therapeutic Class
Neurodegenerative
Company
Shionogi
Structure
Download
2D MOL

3D MOL
Formula
C10H12N2O2S
InChI
InChI=1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1
InChIKey
MNTIJYGEITVWHU-SNVBAGLBSA-N
PubChem Compound ID
637863
PubChem Substance ID
588631, 8704508, 14822776, 15172237, 43760145, 57407683, 80352323, 103319767, 113527700, 128622281, 134339487, 135262860, 140053560, 162223635, 170485610, 178101121, 198985263, 223784473, 232327325, 241376700, 249618015, 252157629, 252160452
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Modulator [536166]
References
Ref 467644(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4304).
Ref 546269Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007184)
Ref 536166Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.

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