Drug General Information
Drug ID	D0M0KB
Former ID	DIB016445
Drug Name	MK-6592
Synonyms	VX-667
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Discontinued in Phase 1	[548341]
Company	Vertex Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Aurora protein kinase	Target Info	Inhibitor	[530317]
KEGG Pathway	Oocyte meiosis
Reactome	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate Formins
WikiPathways	EGF/EGFR Signaling Pathway
	JAK/STAT
	Gastric Cancer Network 1
	Integrated Breast Cancer Pathway
	APC/C-mediated degradation of cell cycle proteins
References
Ref 548341	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024789)
Ref 530317	Clinical experience with aurora kinase inhibitors: a review. Oncologist. 2009 Aug;14(8):780-93.

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