Drug Information

Drug General Information
Drug ID
D0M1RZ
Former ID
DNC001269
Drug Name
SAM486A
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [535793], [540731]
Structure
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2D MOL

3D MOL
Formula
C11H14N6
InChI
InChI=1S/C11H14N6/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17)/b16-9+
InChIKey
CYPGNVSXMAUSJY-CXUHLZMHSA-N
CAS Number
CAS 149400-88-4
PubChem Compound ID
9576789
PubChem Substance ID
7886566, 14749331, 24693748, 26684373, 44714787, 50064476, 50875593, 57373026, 103263058, 103975582, 134339360, 134340478, 135079900, 141857937, 160847746, 162111928, 163394979, 163692549, 163839640, 163843758, 170558735, 172858506, 189659030, 204419641, 223579456, 252499837
Target and Pathway
Target(s) S-adenosylmethioninedecarboxylase proenzyme Target Info Inhibitor [535032]
BioCyc Pathway Methionine salvage cycle III
Spermine biosynthesis
Spermidine biosynthesis
KEGG Pathway Cysteine and methionine metabolism
Arginine and proline metabolism
Metabolic pathways
NetPath Pathway EGFR1 Signaling Pathway
PathWhiz Pathway Spermidine and Spermine Biosynthesis
Methionine Metabolism
WikiPathways Metabolism of amino acids and derivatives
References
Ref 535793S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
Ref 540731(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5268).
Ref 535032A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.

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