Drug Information

Drug General Information
Drug ID
D0M1UA
Former ID
DIB020295
Drug Name
lysophosphatidylinositol
Synonyms
LPI; L-alpha-lysophosphatidylinositol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540631]
Structure
Download
2D MOL
Formula
C11H21O12P
InChI
InChI=1S/C11H21O12P/c1-4(12)21-2-5(13)3-22-24(19,20)23-11-9(17)7(15)6(14)8(16)10(11)18/h5-11,13-18H,2-3H2,1H3,(H,19,20)/t5-,6-,7-,8+,9+,10+,11-/m0/s1
InChIKey
FBDBXJJQMHPGMP-IFUOQLDVSA-N
PubChem Compound ID
73755067
Target and Pathway
Target(s) Glucose-dependent insulinotropic receptor Target Info Agonist [527346]
TRPV2 Target Info Activator [530038]
G-protein coupled receptor 55 Target Info Agonist [532227]
KEGG Pathway cAMP signaling pathway
Insulin secretion
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways Incretin Synthesis, Secretion, and InactivationWP1825:GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540631(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4028).
Ref 527346Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51.
Ref 530038Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009 Mar;1793(3):528-39.
Ref 532227Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.

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