Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M2WZ
|
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| Former ID |
DIB002039
|
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| Drug Name |
NS-2710
|
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| Synonyms |
ME-3127
|
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| Drug Type |
Small molecular drug
|
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| Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Phase 2 | [1] | ||
| Company |
NeuroSearch A/S
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H20N4O
|
||||
| Canonical SMILES |
n1(cnc2c1ccc(c2)/C(=N/OCC)/C)c1cc(c2cnccc2)ccc1
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric-acid receptor alpha-3 subunit | Target Info | Modulator | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activation | |||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | GABAA receptor subtype-selective modulators. I. alpha2/alpha3-selective agonists as non-sedating anxiolytics. Curr Top Med Chem. 2011;11(9):1176-202. | ||||
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