Drug Information

Drug General Information
Drug ID
D0M3XF
Former ID
DNC009872
Drug Name
1-(4-tert-butylphenylsulfonyl)-4-methoxyazepane
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530270]
Structure
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2D MOL

3D MOL
Formula
C17H27NO3S
Canonical SMILES
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)N2CCCC(CC2)OC
InChI
1S/C17H27NO3S/c1-17(2,3)14-7-9-16(10-8-14)22(19,20)18-12-5-6-15(21-4)11-13-18/h7-10,15H,5-6,11-13H2,1-4H3
InChIKey
XPMSNNNCHQEDRB-UHFFFAOYSA-N
PubChem Compound ID
25192606
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [530270]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 530270Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. Epub 2009 Jul 8.The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
Ref 530270Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. Epub 2009 Jul 8.The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.

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